Drug the Undruggable
with Molecular Glue Degraders
ABOUT
Developing Novel Molecular Glue Degraders Against Intractable Targets
Degron Therapeutics is developing a new class of small molecule molecular glue degrader (MGD) drugs using GlueXplorer®, a proprietary molecular glue-based targeted protein degradation drug discovery platform. The company has built a rapidly expanding, structurally differentiated compound library, along with advanced screening and validation systems, to develop novel MGDs aimed at historically intractable but extensively characterized disease targets.
THE PROBLEM
In the past, MGDs have been discovered serendipitously. The rational design of MGDs has been extremely challenging due to the complexity of ternary structure formed by E3 ligase, MGD, and protein substrate (target).
Most MGD development efforts are based on IMiDs' (e.g. lenalidomide) core chemical structure, which leads to limited number of MGD targets and poor lP protection.
OUR APPROACH
GlueXplorer® MGD discovery platform is enabled by:
A biology-backed glue library that includes >10,000 structurally differentiated MGD compounds with associated compound-induced proximity and degradation data.
Comprehensive MGD screening and validation systems.
Large proprietary degradation and proximity data sets for Al/Machine learning.
Developing Novel Molecular Glue Degraders Against Intractable Targets
Degron Therapeutics is developing a new class of small molecule molecular glue degrader (MGD) drugs using GlueXplorer®, a proprietary molecular glue-based targeted protein degradation drug discovery platform. The company has built a rapidly expanding, structurally differentiated compound library, along with advanced screening and validation systems, to develop novel MGDs aimed at historically intractable but extensively characterized disease targets.
THE PROBLEM
In the past, MGDs have been discovered serendipitously. The rational design of MGDs has been extremely challenging due to the complexity of ternary structure formed by E3 ligase, MGD, and protein substrate (target).
Most MGD development efforts are based on IMiDs' (e.g. lenalidomide) core chemical structure, which leads to limited number of MGD targets and poor lP protection.
OUR APPROACH
GlueXplorer® MGD discovery platform is enabled by:
A biology-backed glue library that includes >10,000 structurally differentiated MGD compounds with associated compound-induced proximity and degradation data.
Comprehensive MGD screening and validation systems.
Large proprietary degradation and proximity data sets for Al/Machine learning.
SCIENCE
GlueXplorer® MGD Platform Is Built With Novel Scaffold Chemistry and Enables Novel Targets Discovery
Proprietary
MGD
Library
New
MGD targets
discovery
Targets to
MGDs
Most MGD development efforts are based on IMiDs' (e.g. lenalidomide)  core chemical structure, which leads to limited number of MGD targets and poor lP protection.

Degron has built an unique MGD library based on novel scaffold chemistry. The glue library now includes >10,000 structurally differentiated MGD compounds, with associated compound-induced proximity and degradation data, and is quickly expanding.
Degron has generated large compound-induced proximity and degradation data sets. In addition to producing first-in-class pipeline programs, this proprietary data broadens our understanding on potential MGD target proteins and supports MGD discovery collaborations with industry partners.
MGDs of selected targets are discovered by library screening, glue mechanism of action validation and compound optimization.
PIPELINE
A Robust Pipeline of Programs Targeting Novel and Previously Undruggable Targets
Therapeutic
Area
MGD Target
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
Oncology
HuR (ELAVL1)
First in class
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
HuR (Human antigen R) is a previously undruggable RNA-binding protein playing critical roles in driving cancer, inflammation and metabolic disorders. HuR is over-expressed or cytoplasmic enriched in many cancers particularly in response to stresses including oncogenic mutations and chemo or targeted therapies. HuR is also a well-studied target in inflammatory diseases such as pancreatitis, rheumatoid arthritis, and neuroinflammation.

HuR is considered “undruggable” by conventional approaches. Multiple modalities (RNAi, small molecule inhibitors of translocation, dimerization or RNA binding) have been investigated to target this protein but none has advanced beyond preclinical stage due to various technical challenges.

DEG6498 is a potent and orally bioavailable small molecule molecular glue degrader that induces the interaction between the E3 ubiquitin ligase component cereblon (CRBN) and HuR, leading to the targeted degradation of the HuR protein. In January 2025, Degron received FDA IND clearance for DEG6498 to initiate clinical development in solid tumors. The study will assess its safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity across multiple types of solid tumors.
WEE1
First in class
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
WEE1 kinase phosphorylates and inhibits CDK1 and CDK2 to coordinate cell cycle arrest with DNA damage response. WEE1 molecular glue degrader exhibits a differentiated mechanism of action compared to conventional WEE1 inhibitors. The preclinical candidate is expected to be selected in 1H 2025.
GSPT1
As DAC Payload
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
Validated Target
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
Inflammation
&
Immunology
Validated Target
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
Validated Target
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
Validated Target
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
Multiple Targets in
Neuroscience, Oncology
and Inflammation
Target lD
and Validation
MoA Study
Hit to Lead &
Lead Opt.
Pre-clinical
Development
Phase I
TEAM
Lily Zou, PhD, MBA
CEO, Co-founder
more
Yong Cang, PhD
CSO, Co-founder
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Xiaobing Qian, MD, PhD
CMO/CDO
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Xiaojun Zhang, PhD
Vice President of Chemistry
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Mark Ashwell, PhD
Chemistry Advisor
more
NEWS
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CONTACT
San Diego
3210 Merryfield Row, San Diego, CA 92121
Shanghai
Floor 3, Building 3, Yue Song Life Science Park, 998 Halei Road, Pudong New District, Shanghai, 201203
E-MAIL
bd@degrontx.com
hr@degrontx.com
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©2025 Degron Therapeutics Co.